Epithelial cell extrusion underlies starvation-induced cell loss in a sea anemone
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| Formato: | Recurso digital |
| Lenguaje: | inglés |
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2026
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| _version_ | 1866901909279866880 |
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| author | Fournon-Berodia, Ines Bruderer, Noah Christiaen, Lionel Steinmetz, Patrick R. H. |
| author_facet | Fournon-Berodia, Ines Bruderer, Noah Christiaen, Lionel Steinmetz, Patrick R. H. |
| contents | <p class="MsoNormal"><span>Epithelia likely predate the last common animal ancestor, yet the evolutionary origin and nutritional regulation of epithelial remodelling remain poorly understood. Here, we show that extensive, starvation-induced cell loss in the sea anemone <em>Nematostella vectensis</em> is associated with epidermal cell extrusion. This process involves formation of a rosette-like arrangement in which an apoptotic, extruding cell is surrounded by a phospho-ERK1/2-positive ring of cells, accompanied by basal translocation of adherens junction components. Combining chemical perturbations with computational quantification of extrusion and cell density, we show that apoptosis is necessary but not sufficient for rosette formation, and that ERK1/2 signalling limits epidermal extrusion density. Furthermore, we find </span><span>increased </span><span>extrusion activity during starvation, and </span><span>potential</span> <span>nutrient recycling </span><span>via phagocytosis </span><span>of extruded cells</span><span>. Together, our findings indicate that epithelial cell extrusion has physiological roles in sea anemones and that its key hallmarks are likely evolutionarily ancient, predating the last common </span><span>cnidarian-bilaterian </span><span>ancestor.</span></p> <p class="MsoNormal"><span>This repository contains the rosette identification training dataset, generated through manual annotation of previously segmented images. These annotations were used to train an automated rosette identification model for application across the full dataset.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19726757 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Epithelial cell extrusion underlies starvation-induced cell loss in a sea anemone Fournon-Berodia, Ines Bruderer, Noah Christiaen, Lionel Steinmetz, Patrick R. H. Epithelial remodelling cell extrusion apoptosis ERK signalling TOR signalling starvation sea anemone machine learning image segmentation <p class="MsoNormal"><span>Epithelia likely predate the last common animal ancestor, yet the evolutionary origin and nutritional regulation of epithelial remodelling remain poorly understood. Here, we show that extensive, starvation-induced cell loss in the sea anemone <em>Nematostella vectensis</em> is associated with epidermal cell extrusion. This process involves formation of a rosette-like arrangement in which an apoptotic, extruding cell is surrounded by a phospho-ERK1/2-positive ring of cells, accompanied by basal translocation of adherens junction components. Combining chemical perturbations with computational quantification of extrusion and cell density, we show that apoptosis is necessary but not sufficient for rosette formation, and that ERK1/2 signalling limits epidermal extrusion density. Furthermore, we find </span><span>increased </span><span>extrusion activity during starvation, and </span><span>potential</span> <span>nutrient recycling </span><span>via phagocytosis </span><span>of extruded cells</span><span>. Together, our findings indicate that epithelial cell extrusion has physiological roles in sea anemones and that its key hallmarks are likely evolutionarily ancient, predating the last common </span><span>cnidarian-bilaterian </span><span>ancestor.</span></p> <p class="MsoNormal"><span>This repository contains the rosette identification training dataset, generated through manual annotation of previously segmented images. These annotations were used to train an automated rosette identification model for application across the full dataset.</span></p> |
| title | Epithelial cell extrusion underlies starvation-induced cell loss in a sea anemone |
| topic | Epithelial remodelling cell extrusion apoptosis ERK signalling TOR signalling starvation sea anemone machine learning image segmentation |
| url | https://doi.org/10.5281/zenodo.19726757 |