Astrocyte-Specific Autophagy Enhancement via Berberine-Mediated AMPK/mTOR/ULK1 Pathway Activation
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2026
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| _version_ | 1866901151698386944 |
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| author | MedicOath Autonomous Discovery Engine |
| author_facet | MedicOath Autonomous Discovery Engine |
| contents | Berberine activates AMPK through LKB1 phosphorylation, leading to mTOR inhibition and ULK1 activation. This enhances astrocyte-specific autophagy flux, promoting clearance of misfolded GFAP aggregates and Rosenthal fibers. Additionally, berberine modulates TFEB nuclear translocation to upregulate lysosomal biogenesis genes. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19833272 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Astrocyte-Specific Autophagy Enhancement via Berberine-Mediated AMPK/mTOR/ULK1 Pathway Activation MedicOath Autonomous Discovery Engine Alexander disease drug repurposing MedicOath traditional_medicine Berberine activates AMPK through LKB1 phosphorylation, leading to mTOR inhibition and ULK1 activation. This enhances astrocyte-specific autophagy flux, promoting clearance of misfolded GFAP aggregates and Rosenthal fibers. Additionally, berberine modulates TFEB nuclear translocation to upregulate lysosomal biogenesis genes. |
| title | Astrocyte-Specific Autophagy Enhancement via Berberine-Mediated AMPK/mTOR/ULK1 Pathway Activation |
| topic | Alexander disease drug repurposing MedicOath traditional_medicine |
| url | https://doi.org/10.5281/zenodo.19833272 |