Folate pathway modulation targeting ATIC enzyme enhancement
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2026
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| _version_ | 1866901151575703552 |
|---|---|
| author | MedicOath Autonomous Discovery Engine |
| author_facet | MedicOath Autonomous Discovery Engine |
| contents | High-dose folinic acid increases 10-formyl-THF availability to enhance ATIC enzyme activity in the final step of de novo purine synthesis, potentially compensating for upstream disruptions caused by ADSL deficiency |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19833645 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Folate pathway modulation targeting ATIC enzyme enhancement MedicOath Autonomous Discovery Engine Adenylosuccinate lyase deficiency drug repurposing MedicOath mechanism_extension High-dose folinic acid increases 10-formyl-THF availability to enhance ATIC enzyme activity in the final step of de novo purine synthesis, potentially compensating for upstream disruptions caused by ADSL deficiency |
| title | Folate pathway modulation targeting ATIC enzyme enhancement |
| topic | Adenylosuccinate lyase deficiency drug repurposing MedicOath mechanism_extension |
| url | https://doi.org/10.5281/zenodo.19833645 |