Dentacin: A Trojan-Sugar Hypothesis for Selective Eradication of Streptococcus mutans Within Dentinal Tubules While Preserving Pulp Vitality
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| Format: | Recurso digital |
| Language: | English |
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Zenodo
2026
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| _version_ | 1866901471480512512 |
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| author | Walha, Nesrine |
| author_facet | Walha, Nesrine |
| contents | <p>Root canal treatment remains the standard intervention when dental caries reaches the pulp, yet it irreversibly eliminates pulp vitality. This paper proposes Dentacin — a calcium-functionalized sucrose-Piceatannol ester nanoparticle — designed to selectively eradicate Streptococcus mutans within dentinal tubules through five sequential mechanistic pathways, while preserving the dental pulp entirely. Each pathway is individually supported by existing scientific evidence. A four-phase experimental roadmap is proposed to guide translation from hypothesis to clinical application.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19848401 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Dentacin: A Trojan-Sugar Hypothesis for Selective Eradication of Streptococcus mutans Within Dentinal Tubules While Preserving Pulp Vitality Walha, Nesrine Streptococcus mutans dentinal tubules pulp vitality glucosyltransferase nanoparticle endodontics <p>Root canal treatment remains the standard intervention when dental caries reaches the pulp, yet it irreversibly eliminates pulp vitality. This paper proposes Dentacin — a calcium-functionalized sucrose-Piceatannol ester nanoparticle — designed to selectively eradicate Streptococcus mutans within dentinal tubules through five sequential mechanistic pathways, while preserving the dental pulp entirely. Each pathway is individually supported by existing scientific evidence. A four-phase experimental roadmap is proposed to guide translation from hypothesis to clinical application.</p> |
| title | Dentacin: A Trojan-Sugar Hypothesis for Selective Eradication of Streptococcus mutans Within Dentinal Tubules While Preserving Pulp Vitality |
| topic | Streptococcus mutans dentinal tubules pulp vitality glucosyltransferase nanoparticle endodontics |
| url | https://doi.org/10.5281/zenodo.19848401 |