FORMULATION AND EVALUATION OF POLYMERIC FILMS OF KETOPROFEN TRANSDERMAL PATCHES
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| Langue: | anglais |
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2026
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| _version_ | 1866901540418093056 |
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| author | Dr. A. Sambasivarao*, A. Jaya Prakash, P. Abhinavya, M. Sireesha, S. Akshay Kumar |
| author_facet | Dr. A. Sambasivarao*, A. Jaya Prakash, P. Abhinavya, M. Sireesha, S. Akshay Kumar |
| contents | <p><span>In this study, an attempt was made to develop and evaluate transdermal matrix films of ketoprofen using ethyl cellulose, polyvinyl pyrrolidone and poly1-vinyl pyrrolidone-co-vinyl acetate (Copovidone) to achieve controlled release in order to minimize adverse effects<span> </span>associated<span> </span>with<span> </span>oral<span> </span>administration.<span> </span>Transdermal<span> </span>films<span> </span>of<span> </span>ketoprofen<span> </span>with<span> </span>EC<span> </span>alone<span> </span>and blends of EC: PVP and EC: Copovidone in different ratios of 1:1, 1:2, 1:3 1:6 and 1:9 were prepared by by method of<span> </span>solvent casting on mercury<span> </span>surface. FTIR and DSC were<span> </span>studied to assess any interaction between the drug and the polymers.<span> </span>All prepared films were evaluated for physicochemical characteristics such as physical apprearance, thickness and weight uniformity, folding endurance, water vapor transmission (WVT) studies, SEM analysis and drug content uniformity. <em>The in vitro</em></span> <span>permeation studies through rat abdominal skin were performed by using fabricated Keshary-Chien diffusion cell and obtained results were computed by using dissolution software PCP<span> </span>DISSO<span> </span>V3.<span> </span>The <em>in vitro </em>release data of all films were treated with various kinetic models such as Higuchi, first order, zero order and Korsemeyer-Peppas model. Further <em>in vivo </em>studies like anti-inflammatory, analgesic and skin irritation test were performed for selected EC: PVP and EC: Copovidone films. From the overall <em>in vitro </em>permeation Studies it could be concluded that the polymeric matrix-type transdermal<span> </span>films<span> </span>of<span> </span>ketoprofen<span> </span>prepared<span> </span>with<span> </span>the<span> </span>blends<span> </span>of<span> </span>hydrophobic<span> </span>(EC)<span> </span>and<span> </span>hydrophilic polymers (PVP and Copovidone) in different ratios holds potential for transdermal delivery which<span> </span>gives<span> </span>a<span> </span>slow<span> </span>and<span> </span>controlled<span> </span>release<span> </span>of<span> </span>drug<span> </span>up<span> </span>to<span> </span>24<span> </span>h.<span> </span>Further<span> </span>the<span> </span>present<span> </span>investigations revealed<span> </span>that<span> </span>the<span> </span>problems<span> </span>of<span> </span>ketoprofen<span> </span>on<span> </span>oral<span> </span>administration<span> </span>like<span> </span>gastric<span> </span>side<span> </span>effects<span> </span>can<span> </span>be overcome by applying the drug topically in </span>the form of transdermal film.</p> <p> </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19875276 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | FORMULATION AND EVALUATION OF POLYMERIC FILMS OF KETOPROFEN TRANSDERMAL PATCHES Dr. A. Sambasivarao*, A. Jaya Prakash, P. Abhinavya, M. Sireesha, S. Akshay Kumar <p><span>In this study, an attempt was made to develop and evaluate transdermal matrix films of ketoprofen using ethyl cellulose, polyvinyl pyrrolidone and poly1-vinyl pyrrolidone-co-vinyl acetate (Copovidone) to achieve controlled release in order to minimize adverse effects<span> </span>associated<span> </span>with<span> </span>oral<span> </span>administration.<span> </span>Transdermal<span> </span>films<span> </span>of<span> </span>ketoprofen<span> </span>with<span> </span>EC<span> </span>alone<span> </span>and blends of EC: PVP and EC: Copovidone in different ratios of 1:1, 1:2, 1:3 1:6 and 1:9 were prepared by by method of<span> </span>solvent casting on mercury<span> </span>surface. FTIR and DSC were<span> </span>studied to assess any interaction between the drug and the polymers.<span> </span>All prepared films were evaluated for physicochemical characteristics such as physical apprearance, thickness and weight uniformity, folding endurance, water vapor transmission (WVT) studies, SEM analysis and drug content uniformity. <em>The in vitro</em></span> <span>permeation studies through rat abdominal skin were performed by using fabricated Keshary-Chien diffusion cell and obtained results were computed by using dissolution software PCP<span> </span>DISSO<span> </span>V3.<span> </span>The <em>in vitro </em>release data of all films were treated with various kinetic models such as Higuchi, first order, zero order and Korsemeyer-Peppas model. Further <em>in vivo </em>studies like anti-inflammatory, analgesic and skin irritation test were performed for selected EC: PVP and EC: Copovidone films. From the overall <em>in vitro </em>permeation Studies it could be concluded that the polymeric matrix-type transdermal<span> </span>films<span> </span>of<span> </span>ketoprofen<span> </span>prepared<span> </span>with<span> </span>the<span> </span>blends<span> </span>of<span> </span>hydrophobic<span> </span>(EC)<span> </span>and<span> </span>hydrophilic polymers (PVP and Copovidone) in different ratios holds potential for transdermal delivery which<span> </span>gives<span> </span>a<span> </span>slow<span> </span>and<span> </span>controlled<span> </span>release<span> </span>of<span> </span>drug<span> </span>up<span> </span>to<span> </span>24<span> </span>h.<span> </span>Further<span> </span>the<span> </span>present<span> </span>investigations revealed<span> </span>that<span> </span>the<span> </span>problems<span> </span>of<span> </span>ketoprofen<span> </span>on<span> </span>oral<span> </span>administration<span> </span>like<span> </span>gastric<span> </span>side<span> </span>effects<span> </span>can<span> </span>be overcome by applying the drug topically in </span>the form of transdermal film.</p> <p> </p> |
| title | FORMULATION AND EVALUATION OF POLYMERIC FILMS OF KETOPROFEN TRANSDERMAL PATCHES |
| url | https://doi.org/10.5281/zenodo.19875276 |