DQIS — Addendum I: Temporal Stratification of Tail Dependence Risk
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| Format: | Recurso digital |
| Sprache: | Englisch |
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Zenodo
2026
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| _version_ | 1866901569424850944 |
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| author | DQIS Research Group |
| author_facet | DQIS Research Group |
| contents | <p>Supplementary analysis to the DQIS Consolidated Framework (Zenodo DOI: 10.5281/zenodo.19855263). <br>This addendum addresses the tail dependence concern raised in Section 5.6 of the main document, demonstrating that it decomposes into two mechanistically distinct problems with different temporal signatures: <br>(1) Evolutionary Tail Dependence (ETD): requires sustained selective pressure over many cell generations. At the DQIS early interception window (10² cells, ~10 generations), ETD probability is ~0.03% — negligible for the operational claim. <br>(2) Environmental Tail Dependence (EnTD): arises from shared microenvironmental stressors (hypoxia, acidosis) without mutation. Present from earliest tumor stages; spatially bounded; correctly modeled by Clayton copula. Channels T-β and T-ε identified as most resilient anchor channels. <br>Practical implication: DQIS efficiency claims in the 10²–10³ cell interception window are robust against the ETD objection and require refinement — not invalidation — with respect to EnTD. Not a peer-reviewed publication. Prior art deposit.<br><br>Contact: dqis.research@proton.me<br><br>Related documents: <br>- DQIS Consolidated Framework (main document): https://zenodo.org/records/19877553 <br>- Register of Scientific Objections v4.0: https://zenodo.org/records/19880166 </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19877810 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | DQIS — Addendum I: Temporal Stratification of Tail Dependence Risk DQIS Research Group tail dependence Clayton copula Tumor Microenvironment Hypoxia evolutionary dynamics cancer immunosurveillance <p>Supplementary analysis to the DQIS Consolidated Framework (Zenodo DOI: 10.5281/zenodo.19855263). <br>This addendum addresses the tail dependence concern raised in Section 5.6 of the main document, demonstrating that it decomposes into two mechanistically distinct problems with different temporal signatures: <br>(1) Evolutionary Tail Dependence (ETD): requires sustained selective pressure over many cell generations. At the DQIS early interception window (10² cells, ~10 generations), ETD probability is ~0.03% — negligible for the operational claim. <br>(2) Environmental Tail Dependence (EnTD): arises from shared microenvironmental stressors (hypoxia, acidosis) without mutation. Present from earliest tumor stages; spatially bounded; correctly modeled by Clayton copula. Channels T-β and T-ε identified as most resilient anchor channels. <br>Practical implication: DQIS efficiency claims in the 10²–10³ cell interception window are robust against the ETD objection and require refinement — not invalidation — with respect to EnTD. Not a peer-reviewed publication. Prior art deposit.<br><br>Contact: dqis.research@proton.me<br><br>Related documents: <br>- DQIS Consolidated Framework (main document): https://zenodo.org/records/19877553 <br>- Register of Scientific Objections v4.0: https://zenodo.org/records/19880166 </p> |
| title | DQIS — Addendum I: Temporal Stratification of Tail Dependence Risk |
| topic | tail dependence Clayton copula Tumor Microenvironment Hypoxia evolutionary dynamics cancer immunosurveillance |
| url | https://doi.org/10.5281/zenodo.19877810 |