FORMULATION AND EVALUATION OF SILODOSIN BUCCAL FILM
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| Formato: | Recurso digital |
| Lenguaje: | inglés |
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2026
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| _version_ | 1866901728246366208 |
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| author | Bhargavi Patel1*, Bhakti Shah2, Dr. Shailesh T. Prajapati 3 |
| author_facet | Bhargavi Patel1*, Bhakti Shah2, Dr. Shailesh T. Prajapati 3 |
| contents | <p class="Default"><strong><span>Objective:</span></strong><em><span> </span></em><span>The objective of this research work was to formulate and evaluate buccal film containing Silodosin by enhancement of Permeability by preparing inclusion complex of Silodosin with ꞵ-CD and to increase patient compliance which is useful in the treatment of Hyperplasia.<span> </span><strong>Materials and Methods</strong>: In this research, the method used to prepare buccal films was solvent casting. ꞵ-CD inclusion complex with silodosin in 1:1 ratio to increase permeability of drug. 3<sup>2</sup> Full Factorial design was used for optimization by selecting two independent factors –concentration of film forming agent (HPMC E5)-X I and concentration of plasticizer (Propylene glycol)-X II and their effect on Disintegration time- (R I), and % drug release- (R II). Optimization of factorial batches was done using Design Expert 13 software. <strong>Result</strong>: Best results were obtained in Batch F1 in which HPMC E5 was 150mg and Propylene glycol was 1ml with 31.4 seconds of disintegration time and 99.1 % cumulative drug release at 15 minutes. Check point batch shows 34.74 seconds of disintegration time 97.09 % cumulative drug release. A 1 month accelerated Short term stability study was done on prepared films and it is stable for 1 month. <strong>Conclusion</strong>: Buccal film containing Silodosin were formulated using HPMC E5 as a film forming and Propylene glycol as a plasticizer by solvent casting method. Hence, from the results it was concluded that faster disintegration and faster drug release can be achieved by the buccal film of Silodosin.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19885451 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | FORMULATION AND EVALUATION OF SILODOSIN BUCCAL FILM Bhargavi Patel1*, Bhakti Shah2, Dr. Shailesh T. Prajapati 3 <p class="Default"><strong><span>Objective:</span></strong><em><span> </span></em><span>The objective of this research work was to formulate and evaluate buccal film containing Silodosin by enhancement of Permeability by preparing inclusion complex of Silodosin with ꞵ-CD and to increase patient compliance which is useful in the treatment of Hyperplasia.<span> </span><strong>Materials and Methods</strong>: In this research, the method used to prepare buccal films was solvent casting. ꞵ-CD inclusion complex with silodosin in 1:1 ratio to increase permeability of drug. 3<sup>2</sup> Full Factorial design was used for optimization by selecting two independent factors –concentration of film forming agent (HPMC E5)-X I and concentration of plasticizer (Propylene glycol)-X II and their effect on Disintegration time- (R I), and % drug release- (R II). Optimization of factorial batches was done using Design Expert 13 software. <strong>Result</strong>: Best results were obtained in Batch F1 in which HPMC E5 was 150mg and Propylene glycol was 1ml with 31.4 seconds of disintegration time and 99.1 % cumulative drug release at 15 minutes. Check point batch shows 34.74 seconds of disintegration time 97.09 % cumulative drug release. A 1 month accelerated Short term stability study was done on prepared films and it is stable for 1 month. <strong>Conclusion</strong>: Buccal film containing Silodosin were formulated using HPMC E5 as a film forming and Propylene glycol as a plasticizer by solvent casting method. Hence, from the results it was concluded that faster disintegration and faster drug release can be achieved by the buccal film of Silodosin.</span></p> |
| title | FORMULATION AND EVALUATION OF SILODOSIN BUCCAL FILM |
| url | https://doi.org/10.5281/zenodo.19885451 |