Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Recurso digital |
| Sprache: | |
| Veröffentlicht: |
Zenodo
2026
|
| Online-Zugang: | https://doi.org/10.5281/zenodo.19982489 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Inhaltsangabe:
- <p class="MsoNormal"><span>Quinazoline derivatives constitute an important class of nitrogen-containing heterocycles with well-documented relevance in medicinal chemistry. Owing to their versatile structural framework, these compounds have been reported to exhibit a wide spectrum of biological activities, including antibacterial, antitumor, antiviral, and antiretroviral effects.In the present study, 3-sulphonamido-substituted quinazoline derivatives were synthesized and systematically characterized using melting point determination, thin-layer chromatography (TLC), infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass spectral analysis. Molecular docking studies of the synthesized compounds were performed against the target protein (PDB ID: 1AJO) using AutoDock software to evaluate their binding interactions. Furthermore, the antimicrobial efficacy of the compounds was assessed against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus</span><span>.</span></p>