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| Format: | Recurso digital |
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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.19982489 |
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Table of Contents:
- <p class="MsoNormal"><span>Quinazoline derivatives constitute an important class of nitrogen-containing heterocycles with well-documented relevance in medicinal chemistry. Owing to their versatile structural framework, these compounds have been reported to exhibit a wide spectrum of biological activities, including antibacterial, antitumor, antiviral, and antiretroviral effects.In the present study, 3-sulphonamido-substituted quinazoline derivatives were synthesized and systematically characterized using melting point determination, thin-layer chromatography (TLC), infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass spectral analysis. Molecular docking studies of the synthesized compounds were performed against the target protein (PDB ID: 1AJO) using AutoDock software to evaluate their binding interactions. Furthermore, the antimicrobial efficacy of the compounds was assessed against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus</span><span>.</span></p>