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| Format: | Recurso digital |
| Sprache: | Russisch |
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Zenodo
2026
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| Online-Zugang: | https://doi.org/10.5281/zenodo.19991537 |
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| _version_ | 1866901493136752640 |
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| author | Romannikov, Alexander |
| author_facet | Romannikov, Alexander |
| contents | <p>According to recent estimates, up to 40% of dementia cases may be preventable through the modification of risk factors (Livingston et al., 2020; 2024). However, current prevention models overlook a factor that affects a substantial portion of the population: the architecture of everyday labor. Converging lines of evidence from neuroscience demonstrate that dysfunction of the dopaminergic mesocorticolimbic pathway is a key mechanism underlying apathy and cognitive decline in Alzheimer’s disease (Scattoni et al., 2025; Iaccarino et al., 2021; Stefani et al., 2025). Concurrently, Self-Determination Theory (SDT) and related interventions show that supporting autonomy, competence, and relatedness can mitigate neuropsychiatric symptoms even in advanced dementia (Deci & Ryan, 1985; Haerens et al., 2025; Gitlin et al., 2014). These two evidence streams permit the formulation of a novel hypothesis: a work environment that systematically suppresses agency and subjectivity—exemplified by rigid, externally controlled, and punishment-driven KPI-centric systems—constitutes a prolonged risk factor for neurodegeneration. The article reframes dementia as an architectural rather than a purely medical challenge and introduces the principles of Reflexive-Constructive Methodology (RCM) as tools for designing work ecosystems that support cognitive health. A falsifiable hypothesis is proposed: individuals whose careers unfolded in environments characterized by high autonomy and meaningfulness will demonstrate better preservation of entorhinal cortex function and episodic memory in old age. The paper outlines a concrete observational study design to test this prediction and calls for a paradigm shift in occupational health and organizational design.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19991537 |
| institution | Zenodo |
| language | rus |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Architecture That Kills the Brain: Why KPI-Centered Work Environments Are a Risk Factor for Dementia and How to Redesign Labor for Cognitive Health Romannikov, Alexander KPI work environment dementia prevention dopamine mesocorticolimbic pathway apathy Alzheimer's disease Self-Determination Theory Reflexive-Constructive Methodology cognitive health occupational stress architecture of labor falsifiable hypothesis psychological safety meaning job design <p>According to recent estimates, up to 40% of dementia cases may be preventable through the modification of risk factors (Livingston et al., 2020; 2024). However, current prevention models overlook a factor that affects a substantial portion of the population: the architecture of everyday labor. Converging lines of evidence from neuroscience demonstrate that dysfunction of the dopaminergic mesocorticolimbic pathway is a key mechanism underlying apathy and cognitive decline in Alzheimer’s disease (Scattoni et al., 2025; Iaccarino et al., 2021; Stefani et al., 2025). Concurrently, Self-Determination Theory (SDT) and related interventions show that supporting autonomy, competence, and relatedness can mitigate neuropsychiatric symptoms even in advanced dementia (Deci & Ryan, 1985; Haerens et al., 2025; Gitlin et al., 2014). These two evidence streams permit the formulation of a novel hypothesis: a work environment that systematically suppresses agency and subjectivity—exemplified by rigid, externally controlled, and punishment-driven KPI-centric systems—constitutes a prolonged risk factor for neurodegeneration. The article reframes dementia as an architectural rather than a purely medical challenge and introduces the principles of Reflexive-Constructive Methodology (RCM) as tools for designing work ecosystems that support cognitive health. A falsifiable hypothesis is proposed: individuals whose careers unfolded in environments characterized by high autonomy and meaningfulness will demonstrate better preservation of entorhinal cortex function and episodic memory in old age. The paper outlines a concrete observational study design to test this prediction and calls for a paradigm shift in occupational health and organizational design.</p> |
| title | Architecture That Kills the Brain: Why KPI-Centered Work Environments Are a Risk Factor for Dementia and How to Redesign Labor for Cognitive Health |
| topic | KPI work environment dementia prevention dopamine mesocorticolimbic pathway apathy Alzheimer's disease Self-Determination Theory Reflexive-Constructive Methodology cognitive health occupational stress architecture of labor falsifiable hypothesis psychological safety meaning job design |
| url | https://doi.org/10.5281/zenodo.19991537 |