Zn(II) Complexes of 6-Aminobenzothiazole-Based Schiff Bases: Synthesis, Spectroscopic Characterization, DNA Binding Studies and Biological Investigations
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2026
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| _version_ | 1866901557916729344 |
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| author | K. Jagadesh Babu |
| author_facet | K. Jagadesh Babu |
| contents | Two novel Zn(II) complexes derived from 6-aminobenzothiazole-based Schiff base ligands (HL1 and HL2) were synthesized and comprehensively characterized using spectroscopic and analytical techniques, including mass spectrometry, FT-IR, UV–Vis spectroscopy and thermogravimetric analysis (TGA). The complexes, formulated as [Zn(HL)₂(H₂O)₂], were found to exhibit a six-coordinate octahedral geometry. DNA-binding studies, carried out using electronic absorption and fluorescence spectroscopy, indicated an intercalative mode of interaction, with binding affinities following the order 1a > 2a. The complexes also demonstrated efficient DNA cleavage activity under oxidative and photolytic conditions, showing greater efficacy than the free ligands. In vitro cytotoxicity studies against A549 (lung cancer) and MCF-7 (breast cancer) cell lines revealed enhanced anticancer activity for the Zn(II) complexes. Furthermore, antimicrobial investigations confirmed that the metal complexes possess superior activity compared to their parent ligands. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20000878 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Zn(II) Complexes of 6-Aminobenzothiazole-Based Schiff Bases: Synthesis, Spectroscopic Characterization, DNA Binding Studies and Biological Investigations K. Jagadesh Babu Zn(II) Metal complexes; DNA binding; Anti bacterial; Antifungal; cytotoxic activity. Two novel Zn(II) complexes derived from 6-aminobenzothiazole-based Schiff base ligands (HL1 and HL2) were synthesized and comprehensively characterized using spectroscopic and analytical techniques, including mass spectrometry, FT-IR, UV–Vis spectroscopy and thermogravimetric analysis (TGA). The complexes, formulated as [Zn(HL)₂(H₂O)₂], were found to exhibit a six-coordinate octahedral geometry. DNA-binding studies, carried out using electronic absorption and fluorescence spectroscopy, indicated an intercalative mode of interaction, with binding affinities following the order 1a > 2a. The complexes also demonstrated efficient DNA cleavage activity under oxidative and photolytic conditions, showing greater efficacy than the free ligands. In vitro cytotoxicity studies against A549 (lung cancer) and MCF-7 (breast cancer) cell lines revealed enhanced anticancer activity for the Zn(II) complexes. Furthermore, antimicrobial investigations confirmed that the metal complexes possess superior activity compared to their parent ligands. |
| title | Zn(II) Complexes of 6-Aminobenzothiazole-Based Schiff Bases: Synthesis, Spectroscopic Characterization, DNA Binding Studies and Biological Investigations |
| topic | Zn(II) Metal complexes; DNA binding; Anti bacterial; Antifungal; cytotoxic activity. |
| url | https://doi.org/10.5281/zenodo.20000878 |