Inflammation-Driven Postsynaptic Glutamatergic Dysfunction in Treatment-Resistant Depression: An Integrated Hypothesis Supported by Meta-Analytic Evidence and Novel Clinical Illustrations
Fuente:
Zenodo
Saved in:
| Main Author: | |
|---|---|
| Format: | Recurso digital |
| Published: |
Zenodo
2025
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866901818169098240 |
|---|---|
| author | Abdalmalik, Dafaallah |
| author_facet | Abdalmalik, Dafaallah |
| contents | <p>A groundbreaking integrated hypothesis on Treatment-Resistant Depression (TRD), reviewed and noted as an 'interesting piece' by Professor Mario Maj. This research explores the Inflammation-Glutamate Axis, providing a mechanistic explanation for why conventional antidepressants fail. By bridging meta-analytic data with remarkable clinical transformations—where BDI scores dropped from 35 to 3—this work offers a novel roadmap for neuropsychiatric recovery. This upload includes the full manuscript and supplementary clinical data</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20040535 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Inflammation-Driven Postsynaptic Glutamatergic Dysfunction in Treatment-Resistant Depression: An Integrated Hypothesis Supported by Meta-Analytic Evidence and Novel Clinical Illustrations Abdalmalik, Dafaallah Neuropsychiatry Depressive Disorder Astrocyte dysfunction * Treatment-Resistant Depression Glutamate hypothesis Limitations of the Monoamine Hypothesis Glutamate Excitotoxicity Downregulation of Postsynaptic Receptors <p>A groundbreaking integrated hypothesis on Treatment-Resistant Depression (TRD), reviewed and noted as an 'interesting piece' by Professor Mario Maj. This research explores the Inflammation-Glutamate Axis, providing a mechanistic explanation for why conventional antidepressants fail. By bridging meta-analytic data with remarkable clinical transformations—where BDI scores dropped from 35 to 3—this work offers a novel roadmap for neuropsychiatric recovery. This upload includes the full manuscript and supplementary clinical data</p> |
| title | Inflammation-Driven Postsynaptic Glutamatergic Dysfunction in Treatment-Resistant Depression: An Integrated Hypothesis Supported by Meta-Analytic Evidence and Novel Clinical Illustrations |
| topic | Neuropsychiatry Depressive Disorder Astrocyte dysfunction * Treatment-Resistant Depression Glutamate hypothesis Limitations of the Monoamine Hypothesis Glutamate Excitotoxicity Downregulation of Postsynaptic Receptors |
| url | https://doi.org/10.5281/zenodo.20040535 |