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2026
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| Online Access: | https://doi.org/10.5281/zenodo.20042182 |
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| _version_ | 1866901403651276800 |
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| author | Pranav Kumar Upadhyay, Ashish Gupta* |
| author_facet | Pranav Kumar Upadhyay, Ashish Gupta* |
| contents | <p class="MsoNormal"><span>The present investigation aims to develop and evaluate sustained release matrix tablets of Repaglinide and Miglitol using processed Aloe vera mucilage as a natural release modifier. Both drugs are widely used in the management of Type 2 diabetes mellitus but suffer from short biological half-lives and require frequent administration. The study explores the potential of Aloe vera mucilage as a hydrophilic matrix-forming agent to prolong drug release. Matrix tablets were formulated using wet granulation technique and evaluated for pre-compression and post-compression parameters. In vitro drug release studies demonstrated sustained drug release up to 12 hours. Release kinetics indicated that drug release followed Higuchi diffusion model with non-Fickian transport mechanism. The results suggest that Aloe vera mucilage is an effective, economical, and biocompatible alternative to synthetic polymers for sustained drug delivery.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20042182 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Development and Evaluation of Sustained Release Matrix Tablet of Repaglinide and Miglitol Using Processed Aloe Vera Mucilage as Release Modifier Pranav Kumar Upadhyay, Ashish Gupta* Repaglinide, Miglitol, Aloevera Mucilage <p class="MsoNormal"><span>The present investigation aims to develop and evaluate sustained release matrix tablets of Repaglinide and Miglitol using processed Aloe vera mucilage as a natural release modifier. Both drugs are widely used in the management of Type 2 diabetes mellitus but suffer from short biological half-lives and require frequent administration. The study explores the potential of Aloe vera mucilage as a hydrophilic matrix-forming agent to prolong drug release. Matrix tablets were formulated using wet granulation technique and evaluated for pre-compression and post-compression parameters. In vitro drug release studies demonstrated sustained drug release up to 12 hours. Release kinetics indicated that drug release followed Higuchi diffusion model with non-Fickian transport mechanism. The results suggest that Aloe vera mucilage is an effective, economical, and biocompatible alternative to synthetic polymers for sustained drug delivery.</span></p> |
| title | Development and Evaluation of Sustained Release Matrix Tablet of Repaglinide and Miglitol Using Processed Aloe Vera Mucilage as Release Modifier |
| topic | Repaglinide, Miglitol, Aloevera Mucilage |
| url | https://doi.org/10.5281/zenodo.20042182 |