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2026
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| Online-Zugang: | https://doi.org/10.5281/zenodo.20060073 |
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| _version_ | 1866901491753680896 |
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| author | Mamoor, Shahan |
| author_facet | Mamoor, Shahan |
| contents | <p>We measured total transcription in HPV+ and HPV- head and neck cancers in vivo to understand fundamental properties of cancers resulting from HPV infection. HPV+ head and neck cancers were Bmpr1b- and Igf1-, while HPV- head and neck cancers were Bmpr1b+ and Igf1+. HPV+ head and neck cancers display unique cell cycle regulatory capacity manifested by differential activation repression of the CDKN family (e.g., CDKN2A) and differential control of CDK enzymes including CDK6. HPV+ head and neck cancers were MMP7- and MMP10- while HPV- head and neck cancers were MMP7+ and MMP10+. Immune receptor composition distinguished head and neck cancers: HPV+ cancers were Ildr1+ but Flrt2- Chemokine and cytokine expression distinguished HPV+ and HPV- head and neck cancers; HPV+ head and neck cancers produced large amounts of Cxcl17 but were Cxcl16- and IL6-. We describe here specific control of Taf transcriptional apparatus marked by selective activation of Taf7l in HPV+ head and neck cancers. HPV+ head and neck cancers were Sox30+ and displayed differential control of the myosin machinery (e.g., Myh14). Junctional composition distinguished head and neck cancers resulting from HPV infection: HPV+ head and neck cancers expressed Tjp3 and were Cldn4+. </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20060073 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Major differences between HPV+ and HPV- head and neck cancer. Mamoor, Shahan <p>We measured total transcription in HPV+ and HPV- head and neck cancers in vivo to understand fundamental properties of cancers resulting from HPV infection. HPV+ head and neck cancers were Bmpr1b- and Igf1-, while HPV- head and neck cancers were Bmpr1b+ and Igf1+. HPV+ head and neck cancers display unique cell cycle regulatory capacity manifested by differential activation repression of the CDKN family (e.g., CDKN2A) and differential control of CDK enzymes including CDK6. HPV+ head and neck cancers were MMP7- and MMP10- while HPV- head and neck cancers were MMP7+ and MMP10+. Immune receptor composition distinguished head and neck cancers: HPV+ cancers were Ildr1+ but Flrt2- Chemokine and cytokine expression distinguished HPV+ and HPV- head and neck cancers; HPV+ head and neck cancers produced large amounts of Cxcl17 but were Cxcl16- and IL6-. We describe here specific control of Taf transcriptional apparatus marked by selective activation of Taf7l in HPV+ head and neck cancers. HPV+ head and neck cancers were Sox30+ and displayed differential control of the myosin machinery (e.g., Myh14). Junctional composition distinguished head and neck cancers resulting from HPV infection: HPV+ head and neck cancers expressed Tjp3 and were Cldn4+. </p> |
| title | Major differences between HPV+ and HPV- head and neck cancer. |
| url | https://doi.org/10.5281/zenodo.20060073 |