Lantana camara as a Hepatotoxic and Photosensitizing Weed: Mechanism of Toxicity, Clinical Features, and Implications for Animal Health
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2026
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| author | Anjitha SV, Soorya Gayathri PV, Shafalika Sasi KTK, Kashmeera S Nair, Nandana Ramesh VP, Misriya KA, Ranjith D |
| author_facet | Anjitha SV, Soorya Gayathri PV, Shafalika Sasi KTK, Kashmeera S Nair, Nandana Ramesh VP, Misriya KA, Ranjith D |
| contents | <p><em>Lantana camara</em> is a noxious and highly toxic weed widely distributed across tropical and subtropical regions, posing a serious threat to livestock health and productivity. It contains toxic pentacyclic triterpenoids (lantadenes), which are primarily responsible for its deleterious effects in ruminants. Ingestion of the plant leads to hepatotoxicity characterized by bile duct damage, cholestasis, and impaired liver function. Clinically, affected animals exhibit anorexia, icterus, constipation, and marked photosensitization due to the accumulation of phylloerythrin in the bloodstream. Biochemically, lantana poisoning is associated with a significant elevation of hepatic enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), indicating liver injury. In addition to hepatic damage, renal involvement is evident through increased blood urea nitrogen (BUN) and creatinine levels, suggesting concurrent nephrotoxicity. The combined hepatic and renal dysfunction contribute to reduced productivity, increased morbidity, and occasional mortality in affected livestock. Poisonous plants such as <em>Lantana camara</em> and their secondary metabolites are responsible for considerable economic losses in the livestock sector worldwide. Understanding the toxicodynamics, clinical manifestations, and biochemical alterations associated with lantana poisoning is essential for early diagnosis, effective management, and prevention strategies.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20074309 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
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| spellingShingle | Lantana camara as a Hepatotoxic and Photosensitizing Weed: Mechanism of Toxicity, Clinical Features, and Implications for Animal Health Anjitha SV, Soorya Gayathri PV, Shafalika Sasi KTK, Kashmeera S Nair, Nandana Ramesh VP, Misriya KA, Ranjith D <p><em>Lantana camara</em> is a noxious and highly toxic weed widely distributed across tropical and subtropical regions, posing a serious threat to livestock health and productivity. It contains toxic pentacyclic triterpenoids (lantadenes), which are primarily responsible for its deleterious effects in ruminants. Ingestion of the plant leads to hepatotoxicity characterized by bile duct damage, cholestasis, and impaired liver function. Clinically, affected animals exhibit anorexia, icterus, constipation, and marked photosensitization due to the accumulation of phylloerythrin in the bloodstream. Biochemically, lantana poisoning is associated with a significant elevation of hepatic enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), indicating liver injury. In addition to hepatic damage, renal involvement is evident through increased blood urea nitrogen (BUN) and creatinine levels, suggesting concurrent nephrotoxicity. The combined hepatic and renal dysfunction contribute to reduced productivity, increased morbidity, and occasional mortality in affected livestock. Poisonous plants such as <em>Lantana camara</em> and their secondary metabolites are responsible for considerable economic losses in the livestock sector worldwide. Understanding the toxicodynamics, clinical manifestations, and biochemical alterations associated with lantana poisoning is essential for early diagnosis, effective management, and prevention strategies.</p> |
| title | Lantana camara as a Hepatotoxic and Photosensitizing Weed: Mechanism of Toxicity, Clinical Features, and Implications for Animal Health |
| url | https://doi.org/10.5281/zenodo.20074309 |