Phytopharmaceutical Development and Evaluation of Polyherbal Gel for Wound Healing Therapy (Pipal, Neem, Aloe vera)
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2026
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| author | Shejal Bhaghele*1, Atul Bisen2, Rajesh Mujariya3, Manjeet Singh4 |
| author_facet | Shejal Bhaghele*1, Atul Bisen2, Rajesh Mujariya3, Manjeet Singh4 |
| contents | <p class="MsoNormal"><span>Wound healing is a highly coordinated and complex physiological process that restores the integrity and function of damaged tissues. It progresses through a sequence of overlapping phases, namely hemostasis, inflammation, proliferation, and remodeling. Although several synthetic drugs are available for wound management, their use is often limited by factors such as delayed healing, risk of infection, microbial resistance, and adverse side effects. These limitations have led to increasing interest in alternative therapeutic approaches, particularly those based on natural products. Herbal therapy has emerged as a promising option due to its safety, affordability, and wide range of biological activities. Medicinal plants contain diverse phytoconstituents such as flavonoids, tannins, alkaloids, and phenolic compounds, which play a crucial role in promoting wound healing. These compounds exhibit antimicrobial, anti-inflammatory, antioxidant, and tissue regenerative properties, making them suitable for topical applications. This review aims to explore the potential of a polyherbal gel formulation containing Ficus religiosa (Pipal), Azadirachta indica (Neem), and Aloe vera for wound healing therapy. The concept of a polyherbal formulation is based on synergism, where multiple plant extracts work together to enhance therapeutic efficacy. The gel dosage form offers additional advantages such as ease of application, improved drug penetration, and maintenance of a moist environment conducive to healing. Evidence from various studies suggests that Neem provides strong antimicrobial action, Aloe vera accelerates epithelialization and hydration, and Pipal promotes collagen synthesis and tissue repair. The combined effect of these plants results in faster wound contraction, reduced inflammation, and improved healing quality</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20098864 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
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| spellingShingle | Phytopharmaceutical Development and Evaluation of Polyherbal Gel for Wound Healing Therapy (Pipal, Neem, Aloe vera) Shejal Bhaghele*1, Atul Bisen2, Rajesh Mujariya3, Manjeet Singh4 Polyherbal gel, Wound healing, Ficus religiosa, Azadirachta indica, Aloe vera, Phytopharmaceuticals <p class="MsoNormal"><span>Wound healing is a highly coordinated and complex physiological process that restores the integrity and function of damaged tissues. It progresses through a sequence of overlapping phases, namely hemostasis, inflammation, proliferation, and remodeling. Although several synthetic drugs are available for wound management, their use is often limited by factors such as delayed healing, risk of infection, microbial resistance, and adverse side effects. These limitations have led to increasing interest in alternative therapeutic approaches, particularly those based on natural products. Herbal therapy has emerged as a promising option due to its safety, affordability, and wide range of biological activities. Medicinal plants contain diverse phytoconstituents such as flavonoids, tannins, alkaloids, and phenolic compounds, which play a crucial role in promoting wound healing. These compounds exhibit antimicrobial, anti-inflammatory, antioxidant, and tissue regenerative properties, making them suitable for topical applications. This review aims to explore the potential of a polyherbal gel formulation containing Ficus religiosa (Pipal), Azadirachta indica (Neem), and Aloe vera for wound healing therapy. The concept of a polyherbal formulation is based on synergism, where multiple plant extracts work together to enhance therapeutic efficacy. The gel dosage form offers additional advantages such as ease of application, improved drug penetration, and maintenance of a moist environment conducive to healing. Evidence from various studies suggests that Neem provides strong antimicrobial action, Aloe vera accelerates epithelialization and hydration, and Pipal promotes collagen synthesis and tissue repair. The combined effect of these plants results in faster wound contraction, reduced inflammation, and improved healing quality</span></p> |
| title | Phytopharmaceutical Development and Evaluation of Polyherbal Gel for Wound Healing Therapy (Pipal, Neem, Aloe vera) |
| topic | Polyherbal gel, Wound healing, Ficus religiosa, Azadirachta indica, Aloe vera, Phytopharmaceuticals |
| url | https://doi.org/10.5281/zenodo.20098864 |