DEVELOPMENT, CHARACTERIZATION AND REVIEW OF QUERCETIN-LOADED MIXED MICELLAR EYE DROPS FOR THE TREATMENT OF DRY EYE DISEASE
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2026
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| author | Prof. Sorate Rushikesh Chandrakant*1, Prof. Kulkarni Amar Shripati1, Mr. Patil Rohan Adhikrao1, Mr. Pawar Akash Dattatray1, Ms. Roge Tanvi Hemraj1, Mr. Shete Vijay Dinkar1 |
| author_facet | Prof. Sorate Rushikesh Chandrakant*1, Prof. Kulkarni Amar Shripati1, Mr. Patil Rohan Adhikrao1, Mr. Pawar Akash Dattatray1, Ms. Roge Tanvi Hemraj1, Mr. Shete Vijay Dinkar1 |
| contents | <p><span>Dry<span> </span>Eye<span> </span>Disease<span> </span>(DED)<span> </span>is<span> </span>a<span> </span>multifactorial<span> </span>ocular<span> </span>disorder<span> </span>characterized<span> </span>by<span> </span>tear<span> </span>film<span> </span>instability, inflammation,<span> </span>and<span> </span>oxidative<span> </span>stress,<span> </span>leading<span> </span>to<span> </span>discomfort<span> </span>and<span> </span>visual<span> </span>disturbance.<span> </span>Conventional treatments such as artificial tears provide only temporary relief and fail to address underlying oxidative damage. Quercetin, a natural flavonoid, possesses potent antioxidant and anti-inflammatory properties but suffers from poor aqueous solubility, limiting its therapeutic application in ophthalmic delivery. The present review focuses on the development and evaluation of quercetin-loaded mixed micellar eye drops as a novel drug delivery system for DED. Mixed micelles prepared using non-ionic surfactants such as Polysorbate 80 and Polysorbate 20 enhance solubility, stability, and ocular bioavailability of quercetin. The formulation was evaluated for physicochemical parameters including pH, viscosity, clarity, drug<span> </span>content,<span> </span>micelle<span> </span>size,<span> </span>and<span> </span>in-vitro<span> </span>drug release.<span> </span>The<span> </span>results<span> </span>indicated<span> </span>improved<span> </span>solubility, sustained<span> </span>drug<span> </span>release,<span> </span>and<span> </span>good<span> </span>stability<span> </span>under<span> </span>ICH<span> </span>conditions.<span> </span>Thus,<span> </span>quercetin-loaded<span> </span>mixed micellar<span> </span>systems<span> </span>represent<span> </span>a<span> </span>promising<span> </span>approach<span> </span>for<span> </span>effective<span> </span>management<span> </span>of<span> </span>Dry<span> </span>Eye<span> </span>Disease. However, further clinical studies<span> </span>are<span> </span>required to confirm their safety and therapeutic efficacy.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20156488 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | DEVELOPMENT, CHARACTERIZATION AND REVIEW OF QUERCETIN-LOADED MIXED MICELLAR EYE DROPS FOR THE TREATMENT OF DRY EYE DISEASE Prof. Sorate Rushikesh Chandrakant*1, Prof. Kulkarni Amar Shripati1, Mr. Patil Rohan Adhikrao1, Mr. Pawar Akash Dattatray1, Ms. Roge Tanvi Hemraj1, Mr. Shete Vijay Dinkar1 <p><span>Dry<span> </span>Eye<span> </span>Disease<span> </span>(DED)<span> </span>is<span> </span>a<span> </span>multifactorial<span> </span>ocular<span> </span>disorder<span> </span>characterized<span> </span>by<span> </span>tear<span> </span>film<span> </span>instability, inflammation,<span> </span>and<span> </span>oxidative<span> </span>stress,<span> </span>leading<span> </span>to<span> </span>discomfort<span> </span>and<span> </span>visual<span> </span>disturbance.<span> </span>Conventional treatments such as artificial tears provide only temporary relief and fail to address underlying oxidative damage. Quercetin, a natural flavonoid, possesses potent antioxidant and anti-inflammatory properties but suffers from poor aqueous solubility, limiting its therapeutic application in ophthalmic delivery. The present review focuses on the development and evaluation of quercetin-loaded mixed micellar eye drops as a novel drug delivery system for DED. Mixed micelles prepared using non-ionic surfactants such as Polysorbate 80 and Polysorbate 20 enhance solubility, stability, and ocular bioavailability of quercetin. The formulation was evaluated for physicochemical parameters including pH, viscosity, clarity, drug<span> </span>content,<span> </span>micelle<span> </span>size,<span> </span>and<span> </span>in-vitro<span> </span>drug release.<span> </span>The<span> </span>results<span> </span>indicated<span> </span>improved<span> </span>solubility, sustained<span> </span>drug<span> </span>release,<span> </span>and<span> </span>good<span> </span>stability<span> </span>under<span> </span>ICH<span> </span>conditions.<span> </span>Thus,<span> </span>quercetin-loaded<span> </span>mixed micellar<span> </span>systems<span> </span>represent<span> </span>a<span> </span>promising<span> </span>approach<span> </span>for<span> </span>effective<span> </span>management<span> </span>of<span> </span>Dry<span> </span>Eye<span> </span>Disease. However, further clinical studies<span> </span>are<span> </span>required to confirm their safety and therapeutic efficacy.</span></p> |
| title | DEVELOPMENT, CHARACTERIZATION AND REVIEW OF QUERCETIN-LOADED MIXED MICELLAR EYE DROPS FOR THE TREATMENT OF DRY EYE DISEASE |
| url | https://doi.org/10.5281/zenodo.20156488 |