Saved in:
| Main Author: | |
|---|---|
| Format: | Recurso digital |
| Language: | |
| Published: |
Zenodo
2026
|
| Online Access: | https://doi.org/10.5281/zenodo.20229101 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866901817192873984 |
|---|---|
| author | Lahtee, Yaoharee |
| author_facet | Lahtee, Yaoharee |
| contents | <p>Modern biomedicine has produced a deep, organ-specific knowledge of disease,<br>yet a substantial fraction of clinical suffering — chronic fatigue, persistent pain,<br>post-infectious dysregulation, sleep disruption, brain fog, autonomic instability,<br>and the affective syndromes that accompany them — continues to exceed the<br>explanatory reach of isolated organ models, isolated biomarker panels, and isolated<br>psychiatric categories. This paper proposes Systemic Repair Capacity Theory (SRCT)<br>as a repair-centered systems framework for human health. SRCT defines health<br>not as the absence of disease or the normalization of single markers, but as the<br>organism’s coordinated capacity to restore functional stability after perturbation<br>through interacting layers of blood transport, lymphatic and interstitial clearance,<br>neural regulation, sleep-linked maintenance, immune resolution, metabolic rhythm,<br>environmental safety, and feasible behavior. The theory does not claim novelty<br>at the level of individual biological mechanisms; the vagus nerve, the lymphatic<br>system, glymphatic exchange, neuroimmune signaling, interoception, and circadian<br>metabolism are all established. Its contribution is architectural and epistemological:<br>it integrates these mechanisms into one repair-capacity model, reframes chronic<br>dysregulation as a synchronization failure rather than an isolated lesion, and supplies<br>a measurement strategy — recovery after standardized perturbation — through<br>which the central construct can be operationalized and falsified. We position SRCT<br>against allostatic load, resilience science, psychoneuroimmunology, network medicine,<br>and interoceptive predictive processing; specify six falsifiable predictions and their<br>study designs; and state the framework’s clinical, ethical, and legal boundaries.<br>SRCT is presented as a hypothesis-generating research framework, not a diagnosis,<br>protocol, or substitute for qualified clinical care</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20229101 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Systemic Repair Capacity Theory: A Blood–Lymph–Neural Architecture of Human Health and Chronic Dysregulation Lahtee, Yaoharee <p>Modern biomedicine has produced a deep, organ-specific knowledge of disease,<br>yet a substantial fraction of clinical suffering — chronic fatigue, persistent pain,<br>post-infectious dysregulation, sleep disruption, brain fog, autonomic instability,<br>and the affective syndromes that accompany them — continues to exceed the<br>explanatory reach of isolated organ models, isolated biomarker panels, and isolated<br>psychiatric categories. This paper proposes Systemic Repair Capacity Theory (SRCT)<br>as a repair-centered systems framework for human health. SRCT defines health<br>not as the absence of disease or the normalization of single markers, but as the<br>organism’s coordinated capacity to restore functional stability after perturbation<br>through interacting layers of blood transport, lymphatic and interstitial clearance,<br>neural regulation, sleep-linked maintenance, immune resolution, metabolic rhythm,<br>environmental safety, and feasible behavior. The theory does not claim novelty<br>at the level of individual biological mechanisms; the vagus nerve, the lymphatic<br>system, glymphatic exchange, neuroimmune signaling, interoception, and circadian<br>metabolism are all established. Its contribution is architectural and epistemological:<br>it integrates these mechanisms into one repair-capacity model, reframes chronic<br>dysregulation as a synchronization failure rather than an isolated lesion, and supplies<br>a measurement strategy — recovery after standardized perturbation — through<br>which the central construct can be operationalized and falsified. We position SRCT<br>against allostatic load, resilience science, psychoneuroimmunology, network medicine,<br>and interoceptive predictive processing; specify six falsifiable predictions and their<br>study designs; and state the framework’s clinical, ethical, and legal boundaries.<br>SRCT is presented as a hypothesis-generating research framework, not a diagnosis,<br>protocol, or substitute for qualified clinical care</p> |
| title | Systemic Repair Capacity Theory: A Blood–Lymph–Neural Architecture of Human Health and Chronic Dysregulation |
| url | https://doi.org/10.5281/zenodo.20229101 |