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| Format: | Recurso digital |
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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.20229101 |
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Table of Contents:
- <p>Modern biomedicine has produced a deep, organ-specific knowledge of disease,<br>yet a substantial fraction of clinical suffering — chronic fatigue, persistent pain,<br>post-infectious dysregulation, sleep disruption, brain fog, autonomic instability,<br>and the affective syndromes that accompany them — continues to exceed the<br>explanatory reach of isolated organ models, isolated biomarker panels, and isolated<br>psychiatric categories. This paper proposes Systemic Repair Capacity Theory (SRCT)<br>as a repair-centered systems framework for human health. SRCT defines health<br>not as the absence of disease or the normalization of single markers, but as the<br>organism’s coordinated capacity to restore functional stability after perturbation<br>through interacting layers of blood transport, lymphatic and interstitial clearance,<br>neural regulation, sleep-linked maintenance, immune resolution, metabolic rhythm,<br>environmental safety, and feasible behavior. The theory does not claim novelty<br>at the level of individual biological mechanisms; the vagus nerve, the lymphatic<br>system, glymphatic exchange, neuroimmune signaling, interoception, and circadian<br>metabolism are all established. Its contribution is architectural and epistemological:<br>it integrates these mechanisms into one repair-capacity model, reframes chronic<br>dysregulation as a synchronization failure rather than an isolated lesion, and supplies<br>a measurement strategy — recovery after standardized perturbation — through<br>which the central construct can be operationalized and falsified. We position SRCT<br>against allostatic load, resilience science, psychoneuroimmunology, network medicine,<br>and interoceptive predictive processing; specify six falsifiable predictions and their<br>study designs; and state the framework’s clinical, ethical, and legal boundaries.<br>SRCT is presented as a hypothesis-generating research framework, not a diagnosis,<br>protocol, or substitute for qualified clinical care</p>