Dataset related to article "Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy"
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Recurso digital |
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Zenodo
2026
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| _version_ | 1866902135597170688 |
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| author | Thairi, Cecilia Artioli, Rebecca Paulis, Marianna Galli, Camilla Cotič, Simon Paladino, Alessia Marino, Ilenia Sinagra, Gianfranco Collesi, Chiara Dal Ferro, Matteo Di Pasquale, Elisa |
| author_facet | Thairi, Cecilia Artioli, Rebecca Paulis, Marianna Galli, Camilla Cotič, Simon Paladino, Alessia Marino, Ilenia Sinagra, Gianfranco Collesi, Chiara Dal Ferro, Matteo Di Pasquale, Elisa |
| contents | <p>This record contains raw data related to article “Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy".</p> <h2 class="title">Abstract</h2> <div class="abstract-content selected"> <p>Inherited dilated cardiomyopathy (iDCM) is a disease of the heart muscle, characterized by left ventricle enlargement, systolic dysfunction and arrhythmias. iDCM represents a common cause of heart failure and the most frequent cause of heart transplantation. Among the causative genes, TTN, encoding the sarcomeric protein Titin, represents the most prevalent (about 25 % of cases). The heterogeneous clinical manifestations and variable response to therapy represent a major challenge in patients' clinical management. To deepen the knowledge of this disease, we generated and fully characterized induced Pluripotent Stem Cell lines from 4 iDCM patients carrying 4 different truncating variants of TTN gene.</p> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20261027 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Dataset related to article "Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy" Thairi, Cecilia Artioli, Rebecca Paulis, Marianna Galli, Camilla Cotič, Simon Paladino, Alessia Marino, Ilenia Sinagra, Gianfranco Collesi, Chiara Dal Ferro, Matteo Di Pasquale, Elisa iPSC TTN Genetic Cardiomyopathy truncating mutation <p>This record contains raw data related to article “Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy".</p> <h2 class="title">Abstract</h2> <div class="abstract-content selected"> <p>Inherited dilated cardiomyopathy (iDCM) is a disease of the heart muscle, characterized by left ventricle enlargement, systolic dysfunction and arrhythmias. iDCM represents a common cause of heart failure and the most frequent cause of heart transplantation. Among the causative genes, TTN, encoding the sarcomeric protein Titin, represents the most prevalent (about 25 % of cases). The heterogeneous clinical manifestations and variable response to therapy represent a major challenge in patients' clinical management. To deepen the knowledge of this disease, we generated and fully characterized induced Pluripotent Stem Cell lines from 4 iDCM patients carrying 4 different truncating variants of TTN gene.</p> </div> |
| title | Dataset related to article "Generation of iPSC lines (ICHi001-A, ICHi002-A, ICHi003-A, ICHi004-A) from four patients carrying Titin truncating variants associated with dilated cardiomyopathy" |
| topic | iPSC TTN Genetic Cardiomyopathy truncating mutation |
| url | https://doi.org/10.5281/zenodo.20261027 |