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| Format: | Recurso digital |
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2026
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| Online Access: | https://doi.org/10.5281/zenodo.20272007 |
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| _version_ | 1866901731946790912 |
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| author | Chavan, Swapnil |
| author_facet | Chavan, Swapnil |
| contents | <div>This dataset is derived from PubChem BioAssay AID 743066, titled "qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway".</div> <div> </div> <div> <div>The original assay is part of the Tox21 program and measures activation of thyroid receptor (TR) signaling using a reporter gene assay in a cell-based system. Specifically, TR activation was assessed using a luciferase reporter under the control of thyroid hormone response elements.</div> <div> </div> <div> <div>Original dataset statistics:</div> <div>- Tested compounds: 8,099 - Active (agonists): 58 - Inactive: 7,426</div> <div> </div> <div> <div>Data preprocessing:</div> <div>- Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations.</div> <div> </div> <div> <div>Final cleaned dataset:</div> <div>- Total compounds: 7,260 - Positive (agonists): 37 - Negative (inactive): 7,223</div> <div> </div> </div> </div> </div> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20272007 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Cleaned dataset for PubChem AID 743066: qHTS assay of thyroid receptor (TR) agonists Chavan, Swapnil <div>This dataset is derived from PubChem BioAssay AID 743066, titled "qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway".</div> <div> </div> <div> <div>The original assay is part of the Tox21 program and measures activation of thyroid receptor (TR) signaling using a reporter gene assay in a cell-based system. Specifically, TR activation was assessed using a luciferase reporter under the control of thyroid hormone response elements.</div> <div> </div> <div> <div>Original dataset statistics:</div> <div>- Tested compounds: 8,099 - Active (agonists): 58 - Inactive: 7,426</div> <div> </div> <div> <div>Data preprocessing:</div> <div>- Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations.</div> <div> </div> <div> <div>Final cleaned dataset:</div> <div>- Total compounds: 7,260 - Positive (agonists): 37 - Negative (inactive): 7,223</div> <div> </div> </div> </div> </div> </div> |
| title | Cleaned dataset for PubChem AID 743066: qHTS assay of thyroid receptor (TR) agonists |
| url | https://doi.org/10.5281/zenodo.20272007 |