Saved in:
| Main Author: | |
|---|---|
| Format: | Recurso digital |
| Language: | |
| Published: |
Zenodo
2026
|
| Online Access: | https://doi.org/10.5281/zenodo.20272071 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866902008699551744 |
|---|---|
| author | Chavan, Swapnil |
| author_facet | Chavan, Swapnil |
| contents | <div>This dataset is derived from PubChem BioAssay AID 743067, titled "qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway".</div> <div> </div> <div> <div>The original assay is part of the Tox21 program and evaluates inhibition of thyroid receptor (TR) signaling using a reporter gene assay in a cell-based system. TR activity was measured using a luciferase reporter controlled by thyroid hormone response elements.</div> <div> </div> <div> <div>Original dataset statistics:</div> <div>- Tested compounds: 8,099 - Active (antagonists): 378 - Inactive: 5,631</div> <div> </div> <div> <div>Data preprocessing:</div> <div>- Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations.</div> </div> <div> </div> <div> <div>Final cleaned dataset:</div> <div>- Total compounds: 5,590 - Positive (antagonists): 261 - Negative (inactive): 5,329</div> <div> </div> </div> </div> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20272071 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Cleaned dataset for PubChem AID 743067: qHTS assay of thyroid receptor (TR) antagonists Chavan, Swapnil <div>This dataset is derived from PubChem BioAssay AID 743067, titled "qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway".</div> <div> </div> <div> <div>The original assay is part of the Tox21 program and evaluates inhibition of thyroid receptor (TR) signaling using a reporter gene assay in a cell-based system. TR activity was measured using a luciferase reporter controlled by thyroid hormone response elements.</div> <div> </div> <div> <div>Original dataset statistics:</div> <div>- Tested compounds: 8,099 - Active (antagonists): 378 - Inactive: 5,631</div> <div> </div> <div> <div>Data preprocessing:</div> <div>- Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations.</div> </div> <div> </div> <div> <div>Final cleaned dataset:</div> <div>- Total compounds: 5,590 - Positive (antagonists): 261 - Negative (inactive): 5,329</div> <div> </div> </div> </div> </div> |
| title | Cleaned dataset for PubChem AID 743067: qHTS assay of thyroid receptor (TR) antagonists |
| url | https://doi.org/10.5281/zenodo.20272071 |