yoonalimsuwan/EVOLUTION-ONE: Evolution ONE : Multi‑Level Cancer Evolution & Structural Impact Engine
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| Format: | Recurso digital |
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Zenodo
2026
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| _version_ | 1866902304435732480 |
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| author | Yoon A Limsuwan |
| author_facet | Yoon A Limsuwan |
| contents | <p>Evolution ONE is a standalone, vendor‑neutral platform that models cancer progression through the lens of Self‑Organised Criticality (SOC), duon biology, and physics‑based structural refinement. It ingests genomic mutation data (MAF, VCF) and outputs a complete oncological profile:</p> <p>the evolutionary regime of the tumour (stable, critical, or collapsing),</p> <p>future escape mutations likely to destabilise key proteins,</p> <p>CRISPR‑Cas editing designs (gRNA + repair templates),</p> <p>epigenetic targets for methylation editing,</p> <p>personalised drug and stabiliser recommendations,</p> <p>correlations between lifestyle factors and mutation load.</p> <p>The engine can operate entirely on its own, or optionally leverage REAL FOLD ONE and REAL FOLD ONE HT for atomic‑resolution ΔΔG calculation and high‑throughput mutation scanning.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20283534 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | yoonalimsuwan/EVOLUTION-ONE: Evolution ONE : Multi‑Level Cancer Evolution & Structural Impact Engine Yoon A Limsuwan <p>Evolution ONE is a standalone, vendor‑neutral platform that models cancer progression through the lens of Self‑Organised Criticality (SOC), duon biology, and physics‑based structural refinement. It ingests genomic mutation data (MAF, VCF) and outputs a complete oncological profile:</p> <p>the evolutionary regime of the tumour (stable, critical, or collapsing),</p> <p>future escape mutations likely to destabilise key proteins,</p> <p>CRISPR‑Cas editing designs (gRNA + repair templates),</p> <p>epigenetic targets for methylation editing,</p> <p>personalised drug and stabiliser recommendations,</p> <p>correlations between lifestyle factors and mutation load.</p> <p>The engine can operate entirely on its own, or optionally leverage REAL FOLD ONE and REAL FOLD ONE HT for atomic‑resolution ΔΔG calculation and high‑throughput mutation scanning.</p> |
| title | yoonalimsuwan/EVOLUTION-ONE: Evolution ONE : Multi‑Level Cancer Evolution & Structural Impact Engine |
| url | https://doi.org/10.5281/zenodo.20283534 |