Microencapsulation of Citrus Peel Essential Oils Using Chitosan–Alginate Systems: Mechanistic Insights and Antidiabetic Applications
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2026
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| author | Parampara Barman, Bipul Nath*, Yeduru Krishna Reddy, Swagata Chetia |
| author_facet | Parampara Barman, Bipul Nath*, Yeduru Krishna Reddy, Swagata Chetia |
| contents | <p class="MsoNormal"><span>Diabetes mellitus is a worldwide epidemic metabolic disease characterized by chronic hyperglycemia, oxidative stress and inflammation that leads to debilitating long-term complications. The growing limitations of conventional antidiabetic therapies has stimulated the search for natural phytotherapeutics with multiple biological actions. Citrus peel essential oils (CPEOs) are rich in bioactive compounds (i.e., limonene, linalool, citral and flavonoids) which show significant antioxidant, antihyperglycemic, anti-inflammatory and insulin-sensitizing properties. On the other hand, their pharmaceutical utilization is limited by relatively poor aqueous solubility, volatility and oxidative instability. Chitosan–alginate polyelectrolyte systems have emerged as an effective strategy for the microencapsulation of these volatile phytoconstituents and to improve stability, bioavailability and controlled release. The cationic chitosan is electrostatically attracted to the anionic alginate forming stable biodegradable matrices that can protect essential oils from environmental and gastrointestinal degradation. In summary, the review addresses sources, extraction methods, phytochemical composition and antidiabetic mechanisms of CPEOs with an emphasis on mechanistic insight into chitosan–alginate-based encapsulation systems. In addition, it reviews encapsulation methods; controlled-release profiles; characterization techniques and optimization. This review also focuses on the therapeutic potential of microencapsulated CPEOs towards their use in functional foods, nutraceutical and/or polyherbal antidiabetic formulations as sustainable and targeted natural-product-based delivery systems for advanced diabetes management</span><span>.</span><span> </span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20302771 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Microencapsulation of Citrus Peel Essential Oils Using Chitosan–Alginate Systems: Mechanistic Insights and Antidiabetic Applications Parampara Barman, Bipul Nath*, Yeduru Krishna Reddy, Swagata Chetia Citrus Peel Essential Oils, Chitosan–Alginate Microcapsules, Microencapsulation, Antidiabetic Phytotherapeutics, Controlled Drug Release, Oxidative Stress Management <p class="MsoNormal"><span>Diabetes mellitus is a worldwide epidemic metabolic disease characterized by chronic hyperglycemia, oxidative stress and inflammation that leads to debilitating long-term complications. The growing limitations of conventional antidiabetic therapies has stimulated the search for natural phytotherapeutics with multiple biological actions. Citrus peel essential oils (CPEOs) are rich in bioactive compounds (i.e., limonene, linalool, citral and flavonoids) which show significant antioxidant, antihyperglycemic, anti-inflammatory and insulin-sensitizing properties. On the other hand, their pharmaceutical utilization is limited by relatively poor aqueous solubility, volatility and oxidative instability. Chitosan–alginate polyelectrolyte systems have emerged as an effective strategy for the microencapsulation of these volatile phytoconstituents and to improve stability, bioavailability and controlled release. The cationic chitosan is electrostatically attracted to the anionic alginate forming stable biodegradable matrices that can protect essential oils from environmental and gastrointestinal degradation. In summary, the review addresses sources, extraction methods, phytochemical composition and antidiabetic mechanisms of CPEOs with an emphasis on mechanistic insight into chitosan–alginate-based encapsulation systems. In addition, it reviews encapsulation methods; controlled-release profiles; characterization techniques and optimization. This review also focuses on the therapeutic potential of microencapsulated CPEOs towards their use in functional foods, nutraceutical and/or polyherbal antidiabetic formulations as sustainable and targeted natural-product-based delivery systems for advanced diabetes management</span><span>.</span><span> </span></p> |
| title | Microencapsulation of Citrus Peel Essential Oils Using Chitosan–Alginate Systems: Mechanistic Insights and Antidiabetic Applications |
| topic | Citrus Peel Essential Oils, Chitosan–Alginate Microcapsules, Microencapsulation, Antidiabetic Phytotherapeutics, Controlled Drug Release, Oxidative Stress Management |
| url | https://doi.org/10.5281/zenodo.20302771 |