| _version_ | 1866902041415122944 |
|---|---|
| author | Dominik, Matthew |
| author_facet | Dominik, Matthew |
| contents | <p>This conceptual systems-biology manuscript proposes that severe Ebola virus disease may reflect adaptive overcommitment of a reservoir-calibrated immune suppression strategy encountering a less tolerant human host environment. Building on Adaptive Overcommitment Theory (AOT), the paper reframes Ebola virulence as coupled destabilization of host coordination systems governing immune signaling, endothelial integrity, coagulation stability, hemodynamic resilience, and organ reserve. The framework integrates evolutionary mismatch theory, systems immunology, reservoir-host adaptation, and nonlinear host-collapse dynamics to explore how zoonotic virulence may emerge from host-specific overoptimization rather than primitive pathogenicity.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20319946 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Adaptive Overcommitment in Ebola Virus Disease Dominik, Matthew Ebola virus disease adaptive overcommitment zoonotic spillover systems biology systems immunology reservoir adaptation immune dysregulation interferon suppression host-system collapse virulence evolution bat immunology spillover dynamics host-pathogen interactions endothelial destabilization coagulation dysfunction <p>This conceptual systems-biology manuscript proposes that severe Ebola virus disease may reflect adaptive overcommitment of a reservoir-calibrated immune suppression strategy encountering a less tolerant human host environment. Building on Adaptive Overcommitment Theory (AOT), the paper reframes Ebola virulence as coupled destabilization of host coordination systems governing immune signaling, endothelial integrity, coagulation stability, hemodynamic resilience, and organ reserve. The framework integrates evolutionary mismatch theory, systems immunology, reservoir-host adaptation, and nonlinear host-collapse dynamics to explore how zoonotic virulence may emerge from host-specific overoptimization rather than primitive pathogenicity.</p> |
| title | Adaptive Overcommitment in Ebola Virus Disease |
| topic | Ebola virus disease adaptive overcommitment zoonotic spillover systems biology systems immunology reservoir adaptation immune dysregulation interferon suppression host-system collapse virulence evolution bat immunology spillover dynamics host-pathogen interactions endothelial destabilization coagulation dysfunction |
| url | https://doi.org/10.5281/zenodo.20319946 |