| _version_ | 1866901815607427072 |
|---|---|
| author | Shailender Kumar*, Saurabh Mishra, Mahak Verma, Kanishaka Singh, Ojaswi Singh, Sachin Kumar |
| author_facet | Shailender Kumar*, Saurabh Mishra, Mahak Verma, Kanishaka Singh, Ojaswi Singh, Sachin Kumar |
| contents | <p class="MsoNormal"><span>Transdermal drug delivery systems (TDDS) have emerged as an effective and non-invasive approach for the controlled delivery of therapeutic agents through the skin into systemic circulation. These systems offer several advantages over conventional dosage forms, including avoidance of first-pass metabolism, improved bioavailability, sustained drug release, and enhanced patient compliance. The present review provides a comprehensive overview of transdermal patches for sustained drug delivery, including their concept, components, types, and mechanisms of drug release. The structure and function of the skin as a barrier to drug permeation are also discussed. Furthermore, the advantages, limitations, and challenges associated with transdermal systems are highlighted. Recent advancements such as microneedles, iontophoresis, and sonophoresis have significantly improved drug permeation and expanded the scope of transdermal delivery for macromolecules. In addition, various therapeutic applications, including pain management, hormonal therapy, and cardiovascular treatment, are described. Future perspectives emphasize the development of smart and personalized transdermal patches integrated with advanced technologies. Overall, TDDS represents a promising strategy for sustained and controlled drug delivery in modern therapeutics.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20327015 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Transdermal Patches for Sustained Drug Release: A Comprehensive Review Shailender Kumar*, Saurabh Mishra, Mahak Verma, Kanishaka Singh, Ojaswi Singh, Sachin Kumar Transdermal patches; Sustained release; Drug delivery systems; Skin barrier; Microneedles. <p class="MsoNormal"><span>Transdermal drug delivery systems (TDDS) have emerged as an effective and non-invasive approach for the controlled delivery of therapeutic agents through the skin into systemic circulation. These systems offer several advantages over conventional dosage forms, including avoidance of first-pass metabolism, improved bioavailability, sustained drug release, and enhanced patient compliance. The present review provides a comprehensive overview of transdermal patches for sustained drug delivery, including their concept, components, types, and mechanisms of drug release. The structure and function of the skin as a barrier to drug permeation are also discussed. Furthermore, the advantages, limitations, and challenges associated with transdermal systems are highlighted. Recent advancements such as microneedles, iontophoresis, and sonophoresis have significantly improved drug permeation and expanded the scope of transdermal delivery for macromolecules. In addition, various therapeutic applications, including pain management, hormonal therapy, and cardiovascular treatment, are described. Future perspectives emphasize the development of smart and personalized transdermal patches integrated with advanced technologies. Overall, TDDS represents a promising strategy for sustained and controlled drug delivery in modern therapeutics.</span></p> |
| title | Transdermal Patches for Sustained Drug Release: A Comprehensive Review |
| topic | Transdermal patches; Sustained release; Drug delivery systems; Skin barrier; Microneedles. |
| url | https://doi.org/10.5281/zenodo.20327015 |