| _version_ | 1866902293807366144 |
|---|---|
| author | Merlini, Igor |
| author_facet | Merlini, Igor |
| contents | <p>This repository contains the computational notebooks and supporting data for the paper "Dynamics of the Post-Mortem Transcriptome: A Constrained Manifold Approach to Biological Decay" (Merlini, 2026).</p> <p>Contents:<br>- Notebook 1: C1-Score framework, PCA manifold reconstruction, Lasso regression clock, Shannon entropy analysis, topological robustness (Mantel test)<br>- Notebook 2: Post-mortem network co-expression convergence analysis, null model, Kolmogorov–Smirnov testing</p> <p>The analysis uses publicly available GTEx V8 brain transcriptomic data (dbGaP accession phs000424.v8.p2). All notebooks are fully reproducible and also available on Kaggle (see Related works).</p> <p>Key results: Lasso clock R²=0.924 (MAE=1.39h) on independent validation set; network synchronization Δ|ρ|=+0.057 (Z=4.42, p<0.0001); RIN independence confirmed (r<0.05).</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20411145 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Post-Mortem Transcriptomic Decay Manifold: C1-Score Framework — Code and Data (GTEx V8) Merlini, Igor post-mortem interval, PMI, transcriptomics, GTEx, brain, C1-Score, manifold learning, molecular clock, Shannon entropy, Lasso, network co-expression, systems biology <p>This repository contains the computational notebooks and supporting data for the paper "Dynamics of the Post-Mortem Transcriptome: A Constrained Manifold Approach to Biological Decay" (Merlini, 2026).</p> <p>Contents:<br>- Notebook 1: C1-Score framework, PCA manifold reconstruction, Lasso regression clock, Shannon entropy analysis, topological robustness (Mantel test)<br>- Notebook 2: Post-mortem network co-expression convergence analysis, null model, Kolmogorov–Smirnov testing</p> <p>The analysis uses publicly available GTEx V8 brain transcriptomic data (dbGaP accession phs000424.v8.p2). All notebooks are fully reproducible and also available on Kaggle (see Related works).</p> <p>Key results: Lasso clock R²=0.924 (MAE=1.39h) on independent validation set; network synchronization Δ|ρ|=+0.057 (Z=4.42, p<0.0001); RIN independence confirmed (r<0.05).</p> |
| title | Post-Mortem Transcriptomic Decay Manifold: C1-Score Framework — Code and Data (GTEx V8) |
| topic | post-mortem interval, PMI, transcriptomics, GTEx, brain, C1-Score, manifold learning, molecular clock, Shannon entropy, Lasso, network co-expression, systems biology |
| url | https://doi.org/10.5281/zenodo.20411145 |