Incoherent Failure of the Q2→Q4 Cortical Cascade: A Field-Theoretic Mechanistic Hypothesis for Shaw's ADHD Remission Paradox
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| Format: | Recurso digital |
| Langue: | anglais |
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2026
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| _version_ | 1866902216478031872 |
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| author | Danko, Stjepovic-Gonzalez |
| author_facet | Danko, Stjepovic-Gonzalez |
| contents | <p>v20: Multisite rs-fMRI analysis (ADHD-200, n=346, 4 sites), probabilistic tail analysis (13% left-tail), quartile decomposition (Q1:13%/Q2-Q4:29% each), Figures 4-5 embedded, ethical framework §6.4 (WIN-WIN, French precautionary principle), 8 falsifiable predictions, Sibley et al. 2024, Cao et al. 2024, Tomasi et al. 2025. Submitted to Frontiers in Human Neuroscience 27 May 2026.</p> <p>We propose a mechanistic hypothesis for the Shaw ADHD remission paradox — the observation that apparent cortical normalization in adolescence does not guarantee functional remission in adulthood. Within the Cortical Informational Field Theory (CIFT) framework, we formalize two failure modes: coherent failure (Persistent ADHD: Q2+Q4 both subcritical) and incoherent failure (Remitter: Q4 subcritical without Q2 scaffolding). Cortical field simulations (n=15, γ_W=0.15) demonstrate that Remitters show significantly lower MI(E,W)|Q4 than Persistents (t=−4.97, p<0.001, d=−1.81), a finding robust across 9 parameter sweeps. Pharmacological screening of ADHD-200 TCIC (ds002424, n=147) reveals asymmetric drug effects: MPH/AMP partially stabilize Q4 dynamics with no detectable effect on Q2 — the boundary condition that determines long-term gradient coupling. Five falsifiable predictions are proposed</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_20416400 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Incoherent Failure of the Q2→Q4 Cortical Cascade: A Field-Theoretic Mechanistic Hypothesis for Shaw's ADHD Remission Paradox Danko, Stjepovic-Gonzalez ADHD cortical field theory CIFT remission paradox Shaw Q2→Q4 cascade computational neuroscience Ginzburg-Landau incoherent failure pharmacology methylphenidate <p>v20: Multisite rs-fMRI analysis (ADHD-200, n=346, 4 sites), probabilistic tail analysis (13% left-tail), quartile decomposition (Q1:13%/Q2-Q4:29% each), Figures 4-5 embedded, ethical framework §6.4 (WIN-WIN, French precautionary principle), 8 falsifiable predictions, Sibley et al. 2024, Cao et al. 2024, Tomasi et al. 2025. Submitted to Frontiers in Human Neuroscience 27 May 2026.</p> <p>We propose a mechanistic hypothesis for the Shaw ADHD remission paradox — the observation that apparent cortical normalization in adolescence does not guarantee functional remission in adulthood. Within the Cortical Informational Field Theory (CIFT) framework, we formalize two failure modes: coherent failure (Persistent ADHD: Q2+Q4 both subcritical) and incoherent failure (Remitter: Q4 subcritical without Q2 scaffolding). Cortical field simulations (n=15, γ_W=0.15) demonstrate that Remitters show significantly lower MI(E,W)|Q4 than Persistents (t=−4.97, p<0.001, d=−1.81), a finding robust across 9 parameter sweeps. Pharmacological screening of ADHD-200 TCIC (ds002424, n=147) reveals asymmetric drug effects: MPH/AMP partially stabilize Q4 dynamics with no detectable effect on Q2 — the boundary condition that determines long-term gradient coupling. Five falsifiable predictions are proposed</p> |
| title | Incoherent Failure of the Q2→Q4 Cortical Cascade: A Field-Theoretic Mechanistic Hypothesis for Shaw's ADHD Remission Paradox |
| topic | ADHD cortical field theory CIFT remission paradox Shaw Q2→Q4 cascade computational neuroscience Ginzburg-Landau incoherent failure pharmacology methylphenidate |
| url | https://doi.org/10.5281/zenodo.20416400 |