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| Main Authors: | , , , |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Peptides
2026
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| Subjects: | |
| Online Access: | https://pubmed.ncbi.nlm.nih.gov/41520995/ |
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Table of Contents:
- Oral salmon acylated ghrelin increases food intake in common carp (Cyprinus carpio) via ghrelin receptors, likely through sensory nerves rather than systemic absorption. Kihara, Minoru Yamagiwa, Teppei Katayama, Hidekazu Kaiya, Hiroyuki Animals Ghrelin Carps Receptors, Ghrelin Eating Salmon Administration, Oral Sensory Receptor Cells Capsaicin Oligopeptides This study clarified the local mechanism of action and assessed the aquaculture potential of orally administered salmon acylated ghrelin (sAG) on feed intake in common carp (Cyprinus carpio). Experimental diets containing sAG (ranging from 0.001 to 13.04 µg/g) were prepared and fed to carp at 2.0 % of body weight (BW) in single-shot trials. Fish receiving diets of 0.64 µg/g (1.3 µg/100 g BW) or higher exhibited a significant, dose-dependent increase in additional feed intake, plateauing at 1.20 µg/g (2.4 µg/100 g BW). Despite this behavioral effect, plasma ghrelin levels remained unchanged, as measured by both N-terminal and salmon-specific C-terminal radioimmunoassays, confirming that sAG was not systemically absorbed. The orexigenic effect was abolished by pretreatment with the ghrelin receptor antagonist [D-Lys3]-GHRP-6 or with capsaicin, demonstrating local sAG action via growth hormone secretagogue receptor signaling and peripheral sensory neurons (likely vagal afferents). These findings provide the first evidence that fish ghrelin exerts biological activity via a non-circulatory neuroendocrine pathway. This advances our understanding of the vertebrate gut-brain axis and highlights the potential of harnessing locally acting peptides for physiological modulation in aquatic species.